| 摘要 |
Embodiments of the present invention include methods and systems for analysis of comparative genomic hybridization ("CGH") data, including CGH data obtained from microarray experiments. Various embodiments of the present invention include parametric and non-parametric normalization methods for CGH data, methods for identifying sets of one or more contiguous chromosomal DNA subsequences that are amplified or deleted in cells from particular tissue samples, and methods for determining amplifications and deletions common to a set of analyzed samples. When combined with well-designed microarray-based experimental systems, method embodiments of the present invention provide markedly increased quantitative precision in the identification of chromosomal abnormalities, including amplified and deleted DNA subsequences based on CGH data. |
