ARYLQUINOLINE, ARYLQUINOLONE AND ARYLTHIOQUINOLONE DERIVATIVES AND USE THEREOF TO TREAT CANCER

摘要

Arylquinoline derivatives and their use for treating cancer or cancer metastasis is disclosed. The compounds of the subject technology promote cells to secrete a pro-apoptotic tumor suppressor, i.e., prostate apoptosis response-4 (Par-4), which in turn promote apoptosis in cancer cells or metastatic cells.

主权项

1. A compound according to formula (I): or a pharmaceutically acceptable salt thereof; wherein n is 1, 2, or 3, for each NR1R2, R1 and R2 are independently H, alkyl, alkoxy, aryl, heteroaryl; Ar is aryl or heteroaryl, which can be further substituted with halogen, amino, alkylamino, dialkylamino, arylalkylamino, N-oxides of dialkylamino, trialkylammoniurn, mercapto, alkylthio, alkanoyl, nitro, nitrosyl, cyano, alkoxy, alkenyloxy, aryl, heteroaryl, sulfonyl, sulfonamide, CONR3R4, NR3CO(R4), NR3COO(R4), NR3CONR4R5 where R3, R4, R5, are independently, H, alkyl, aryl, heteroaryl or a fluorine; X represents halogen; m is 1, 2, 3, 4, or 5; o is 1, 2, 3 or 4; and each Y is independently a halogen, alkoxy, alkylthio, a substituted or unsubstituted heterocycle.