发明名称 |
PEG-Urate Oxidase Conjugates and Use Thereof |
摘要 |
A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG), wherein an average of 2 to 10 strands of PEG are conjugated to each uricase subunit and the PEG has an average molecular weight between about 5 kDa and 100 kDa. The resulting PEG-uricase conjugates are substantially non-immunogenic and retain at least 75% of the uricolytic activity of the unmodified enzyme. |
申请公布号 |
US2016160188(A1) |
申请公布日期 |
2016.06.09 |
申请号 |
US201514806494 |
申请日期 |
2015.07.22 |
申请人 |
Duke University ;Crealta Pharmaceuticals LLC |
发明人 |
WILLIAMS L. David;Hershfield Michael S.;Kelly Susan J.;Saifer Mark G.P.;Sherman Merry R. |
分类号 |
C12N9/06;C12N9/96 |
主分类号 |
C12N9/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Durham NC US |