METHOD FOR INDUCING OLIGODENDROCYTE PRECURSOR CELLS FROM OCT4-INDUCED HUMAN SOMATIC CELLS THROUGH DIRECT REPROGRAMMING

摘要

The present invention relates to a method for inducing oligodendrocyte precursor cells from human somatic cells, into which a nucleic acid molecule coding Oct4 protein is introduced, or human somatic cells treated with Oct4 protein, through direct reprogramming. The method for inducing oligodendrocyte precursor cells by treating Oct4-overexpressed human somatic cells with a low-molecular weight material, according to the present invention, can establish oligodendrocyte precursor cells at high efficiency for a short period of time, through direct reprogramming without going through neural stem cells, and thus the oligodendrocyte precursor cells are useful as a cell therapeutic agent for intractable demyelinating diseases.