发明名称 |
Single-chain TRAIL-receptor agonist proteins |
摘要 |
Provided herein are specific TRAIL receptor agonist proteins, nucleic acids encoding the same, and methods of treating a subject having a TRAIL-associated disease or disorder. The TRAIL receptor agonist proteins provided herein comprise three soluble TRAIL domains and an Fc fragment. The TRAIL receptor agonist proteins are substantially non-aggregating and suitable for therapeutic, diagnostic and/or research applications. |
申请公布号 |
AU2015249649(A1) |
申请公布日期 |
2016.11.10 |
申请号 |
AU20150249649 |
申请日期 |
2015.04.23 |
申请人 |
AbbVie Inc.;Apogenix AG |
发明人 |
Hill, Oliver;Gieffers, Christian;Thiemann, Meinolf;Buchanan, Fritz G.;Phillips, Darren C.;Lappe, Susan E. |
分类号 |
C07K14/705;A61K38/00;A61K38/19 |
主分类号 |
C07K14/705 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|