发明名称 |
GENETICALLY ENGINEERED C1-UTILIZING MICROORGANISMS AND PROCESSES FOR THEIR PRODUCTION AND USE |
摘要 |
Described are genetically engineered C1 -utilizing bacteria for the preparation of dicarboxylic acids, e.g. succinic acid. For instance, the bacteria comprise a mutation in a gene encoding a tricarboxylic acid cycle (TCA) succinate dehydrogenase (Sdh), preferably a mutation which inactivates or reduces Sdh's activity. Processes for the production of the modified bacteria as well as their use in the preparation of succinic acid on a C1 -compound as carbon source are also discussed. |
申请公布号 |
WO2016165025(A1) |
申请公布日期 |
2016.10.20 |
申请号 |
WO2016CA50439 |
申请日期 |
2016.04.15 |
申请人 |
NATIONAL RESEARCH COUNCIL OF CANADA |
发明人 |
LAMARCHE, Martin G.;PERREAULT, Jonathan;MIGUEZ, Carlos |
分类号 |
C12N1/21;C12N9/00;C12N9/02;C12N9/10;C12N9/88;C12N15/00;C12N15/52;C12N15/53;C12N15/54;C12N15/60;C12N15/63;C12P7/46 |
主分类号 |
C12N1/21 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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