| 发明名称 |
PHARMACEUTICAL COMPOSITIONS |
| 摘要 |
The present invention relates to crosslinked polyamine particles and/or pharmaceutical compositions comprising, at least in part, crosslinked polyamine particles and aggregates of such particles (including cured aggregates of crosslinked polyamine particles). The compositions may be in the form of tablets comprising, for example, particles larger than 500 μm, and used for treating patients, for example, patients with hyperphosphatemia. |
| 申请公布号 |
US2016158275(A1) |
申请公布日期 |
2016.06.09 |
| 申请号 |
US201514968170 |
申请日期 |
2015.12.14 |
| 申请人 |
GENZYME CORPORATION |
发明人 |
HOLMES-FARLEY Stephen Randall;HARRIS David J.;POLOMOSCANIK Steven C.;SALAMEH Adnan;SHUTTS Bruce;SILVA Richard;DHAL Pradeep K.;SOLE Lynne |
| 分类号 |
A61K31/785;A61K9/20;B01J41/14;A61K9/16 |
主分类号 |
A61K31/785 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A pharmaceutical composition comprising a crosslinked amine polymer comprising:
i. repeat units represented by the following Formula I and/or Formula II: wherein m is an integer from 0 to 2; n is an integer and each R1, R2 and R3 independently represent hydrogen; substituted or unsubstituted, branched or unbranched C1-C6 alkyl; substituted or unsubstituted, branched or unbranched C1-C6 alkylamino; X− is a pharmaceutically acceptable counterion; and ii. a crosslinking agent or residue thereof; wherein said crosslinked amine polymer comprises particles having a dry particle size distribution wherein greater than 10 vol. % of the particles have a particle size larger than 600 μm. |
| 地址 |
Cambridge MA US |
