Antibodies Against PD-1 and Uses Thereof

摘要

The present invention provides antibodies and antigen-binding fragments that specifically bind PD-1 (Programmed Death 1), thereby modulating immune responses in general, and those mediated by TcR and CD28, in particular. The disclosed compositions and methods may be used for example, in treating autoimmune diseases, inflammatory disorders, allergies, transplant rejection, cancer and other immune system disorders.

主权项

1. An isolated antibody or antigen-binding fragment thereof that specifically binds to a PD-1 polypeptide and comprises a VH and/or a VL domain, where the VH and/or VL domain are each identical to or each have at least 90%, 95%, or 98% identity to the VH and VL amino acid sequences of SEQ ID NOs: 7 and 9.