发明名称 |
Rocuronium formulation with improved stability |
摘要 |
The present invention provides a rocuronium formulation having excellent stability. This formulation includes rocuronium and a buffer solution, and has a pH adjusted to 3.5 or less (for example, 2.5-3.5). The buffer solution may be a citric acid/sodium hydroxide buffer solution, a tartaric acid/sodium hydroxide buffer solution, a potassium hydrogen phthalate/hydrochloric acid buffer solution, a glycine/hydrochloric acid buffer solution or the like. This type of rocuronium formulation has a rocuronium analog C generation rate of 5% or less after being stored for six months at 40 °C, for example. |
申请公布号 |
AU2014398349(A1) |
申请公布日期 |
2016.12.01 |
申请号 |
AU20140398349 |
申请日期 |
2014.06.26 |
申请人 |
Maruishi Pharmaceutical Co., Ltd. |
发明人 |
Itsuji, Yutaka;Nagahara, Hironori;Jinbo, Keisuke |
分类号 |
A61K31/5355;A61K9/08;A61K47/12;A61K47/18;A61P23/00 |
主分类号 |
A61K31/5355 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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