| 摘要 |
The invention discloses pyridines substituted at the 2-position and also having an aryl substituent at the 5-position and cyano at the 3-position, e.g., [3-cyano-5-(p-chlorophenyl)-2-pyridyloxy]acetic acid ethyl ester and 5-phenyl-2-dimethylamino-ethylamino-nicotinonitrile. Such pyridine derivatives are useful as pharmaceutical agents, e.g., as anti-inflammatory agents. The compounds may be prepared by reacting a 2-halo-5-aryl-nicotinonitrile with the appropriate derivative of the substituent desired at the 2-position according to established procedures.
|
