4'-(2-hydroxy-3-isopropylaminopropoxy)-acetanilide prepn - - from para-acetamidophenolates, halohydrins or epoxides

摘要

41-(2-Hydroxy-3-isopropylaminopropoxy)-acetanilide) (i.e. practolol), a known beta-adrenergic blocking agent, is produced economically and in good yield and purity by reacting an alkali salt of p-acetamidophenol with 1-(chloro- or bromo)-2-hydroxy-3-isopropylaminopropane or with 1,2-epoxy-3-isopropylaminopropane in a suitable solvent. The reaction is pref. carried out at room temp. in water and/or a water-miscible solvent, and practolol can be isolated by e.g., saturating the reaction mixture with K2CO3 and extracting with a solvent such as CHCl3.