| 摘要 |
1394384 Substituted xanthone-2-carboxylic acid compounds SYNTEX (USA) Inc 12 July 1972 [3 March 1972 5 June 1972] 44674/74 Divided out of 1394383 Heading C2C The invention comprises compounds of the formula wherein R is SO 3 H, SO 2 NH 2 or mono- or di- (C 1 -C 8 ) alkyl-sulphamoyl; and non-toxic esters, amides and salts thereof. They may be obtained by treating 6-mercaptoxanthone-2-carboxylic acid with Cl 2 under acidic conditions to give 6 - chlorosulphonylxanthone - 2 - carboxylic acid, and either treating the latter with an inorganic base other than NH 3 to give 6-sulphoxanthone - 2 - carboxylic acid; or treating the latter with NH 3 , or a mono- or dialkylamine to give the corresponding 6-sulphamoyl, or -mono- or di - alkylsulphamoyl - xanthone - 2- carboxylic acid; and optionally converting the products to non-toxic esters, amides or salts thereof. Examples are given for the production of the compounds. Pharmaceutical compositions comprise the compounds of the above formula which may be administered orally, parenterally, topically or by inhalation in conventional forms optionally together with other pharmaceutical agents.
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