摘要 |
1399261 Cardiovascular medicines SCIENCE UNION ET CIE SOC FRANCAISE DE RECHERCHE MEDICALE 23 Jan 1973 [24 Jan 1972] 3237/72 Heading A5B [Also in Division C2] Pharmaceutical compositions having cardiovascular properties for oral, parenteral, sublingual or rectal administration comprise a compound of formula I wherein Y, Y' and Y" are independently H, halogen, optionally substituted C 1 -C 6 alkyl, C 1 -C 6 alkoxy or CF 3 radical; R, which may be in the 5-, 10- or 11-position is a radical of general formula II wherein R, is H or an optionally substituted C 1 -C 6 alkyl, R 2 is H, optionally substituted C 1 -C 6 alkyl, C 2-10 alkenyl or benzyl radical, R 3 is optionally substituted C 1 -C 6 alkyl, C 2 -C 10 alkenyl, C 2 -C alkynyl or aryl-C 1 -C 6 alkyl radical or R 2 -N-R 3 represents a 5-7 membered heterocyclic ring which optionally contains a further hetero atom selected from O, N-S, the dotted line indicating an optional double bond, or acid addition salt thereof together with a pharmaceutically acceptable carrier and optionally another active ingredient having similar or synergistic properties such as a #-receptor blocker (e.g. propanolol or practolol), a coronarydilator (e.g. dipyridamol or a nitrated polyol), an anticoagulant agent (e.g. ethyl bis coumacetate or Acenocoamarol) or a compound which has a pharmacological action similar to that of digitalin.
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