| 发明名称 |
COMPOSITIONS AND METHODS FOR INHIBITING JC VIRUS (JCV) |
| 摘要 |
The instant invention provides compositions and methods for inhibiting the JC Virus (JCV), and that can be used, for example, for treating progressive multifocal leukoencephalopathy (PML). Antisense oligonucleotides are provided which are effective in inhibiting JCV replication or multiplication, alone or in a combination. In preferred embodiments, the oligonucleotides contain modifications. |
| 申请公布号 |
US2016272974(A1) |
申请公布日期 |
2016.09.22 |
| 申请号 |
US201415023352 |
申请日期 |
2014.09.19 |
| 申请人 |
THE U.S.A., AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES |
发明人 |
Jaeger Laura B.;Nath Avindra;Major Eugene;Kuschner-Monaco Maria Chiara;Ferenczy Michael W. |
| 分类号 |
C12N15/113 |
主分类号 |
C12N15/113 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. An antisense oligonucleotide which is targeted to a nucleic acid encoding polyomavirus JC (JCV), and is capable of inhibiting JCV replication and multiplication. |
| 地址 |
Rockville MD US |
