SOLUBLE HIV-1 ENVELOPE GLYCOPROTEIN TRIMERS

摘要

The present application relates to novel HIV-1 envelope glycoproteins which may be utilized as an HIV-1 vaccine immunogens, antigens for crystallization and for the identification of broad neutralizing antibodies. The present invention encompasses the preparation and purification of immunogenic compositions which are formulated into the vaccines of the present invention.

主权项

1. An engineered or non-naturally occurring trimer, wherein the trimer is a disulfide stabilized SOSIP trimer and/or a flexibly linked NFL2P trimer derived from the subtype A BG505 Env, wherein the trimer comprises one or more BG505 or JRFL trimer-derived mutations (“TD mutations”), wherein said TD mutations comprise one or more mutations at residue 47, 49, 65, 106, 164, 165, 172, 302, 308, 429, 432, 500, 519, 520, 543, 553, 567, 588 and/or 662.