VEHICLE SUBSTANCES WHICH ARE CAPABLE OF COVALENT BONDING WITH BIOLOGICALLY ACTIVE MATTER AND THEIR PREPARATION

摘要

Process for preparing a vehicle substance capable of covalent bonding with biological material, especially enzymes, by reacting a matrix containing -OH or NH2 groups with an organic diisocyanate under anhydrous conditions. The distance between the matrix and biological material may be extended by a stepwise reaction of the matrix with an organic diisocyanate, and organic spacer containing two or more -OH and/or NH2 groups and again with an organic diisocyanate. The coupling of the vehicle material with biological material takes place in buffered aqueous solution.