ENGINEERED BACTERIA FOR PRODUCTION AND RELEASE OF THERAPEUTICS
摘要
Some embodiments described herein relate to cells which have been genetically engineered to release a polypeptide when a population of the cells reaches a desired density. In some embodiments, the released polypeptide may be a therapeutic polypeptide. In some embodiments, the therapeutic polypeptide kills tumor cells or which inhibits the growth of tumor cells.
申请公布号
WO2016164636(A1)
申请公布日期
2016.10.13
申请号
WO2016US26518
申请日期
2016.04.07
申请人
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人
HASTY, Jeff;TSIMRING, Lev;DIN, Muhammad, Omar;PRINDLE, Arthur;BHATIA, Sangeeta;DANINO, Tal