发明名称 |
Carbohydrate derivatives of milbemycin and processes therefor |
摘要 |
Carbohydrate derivatives of the antibiotic substance milbemycin, also identified as B-41, and of 13-hydroxy milbemycin are prepared. The carbohydrate groups are attached to the available hydroxy groups of milbemycin and to the hydroxy group synthesized at the 13-position. The reactions may be made selectively such that more than one carbohydrate group may be attached to a single position, or that multiple carbohydrate groups may be attached at different positions on the molecule. The described carbohydrate derivatives have antiparasitic activity.
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申请公布号 |
US4156720(A) |
申请公布日期 |
1979.05.29 |
申请号 |
US19770852403 |
申请日期 |
1977.11.17 |
申请人 |
MERCK & CO INC |
发明人 |
FISHER, MICHAEL H;TOLMAN, RICHARD L |
分类号 |
C07D493/20;C07H17/08;(IPC1-7):A61K31/70;C07G11/00 |
主分类号 |
C07D493/20 |
代理机构 |
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代理人 |
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地址 |
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