发明名称 |
1-Methyl:indolyl:oxy-2,3-epoxy-propane prodn. - from 4-hydroxy-2-methyl:indole and epichlorohydrin in protic solvent |
摘要 |
<p>Prodn. of 1-(2-methylindol-4-yloxy)-2,3-epoxypropane (I) comprises reacting 4-hydroxy-2-methylindole (II) and epichlorohydrin (III) in a protic solvent in presence of an alkali metal salt of a weak acid or of Al2O3, at above room temp. (I) is an intermediate for mepindolol (4-(2-hydroxy-3-isopropylaminopropxy)-2-methylindole). This process is quicker and gives better yields than the known reaction of (II) and (III) at room temp. in presence of aq. NaOH.</p> |
申请公布号 |
DE2905053(A1) |
申请公布日期 |
1980.08.14 |
申请号 |
DE19792905053 |
申请日期 |
1979.02.08 |
申请人 |
SCHERING AG |
发明人 |
JUNGHANS,KLAUS,DR.;HADER,JOSEF,DR. |
分类号 |
C07D405/12;(IPC1-7):C07D405/12 |
主分类号 |
C07D405/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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