| 摘要 |
Cephalosporins(I; Ar = 2-thienyl, 3-thienyl, Ph, p-acyloxyphenyl; COB1 and COB2 are carboxyl, protected carboxyl; R = H, lower alkyl) were prepd. by the reaction of II and III. Thus, 235 mg 7α-methoxy-7β[α-(3-thienyl)-α-diphenylmethoxy-carbonylacetamido -3-(1,3,4-thiadiazol-2-yl) thiomethyl-1-dethia-1-oxa-3-cephem-4-4-carboxylate, 1 ml anisole and trifluoroacetic acid were reacted in 1.5 ml methylene chloride at 0oC for 1 hr to give 140 mg 7α-methoxy-7β-[α-carboxy-α-(3-thienyl)-acetamido -3-(1,3,4-thiadiazol-2-yl)thiomethyl-1-dethia-1-oxa-3-cephem-4-carboxylic acid.
|
