发明名称 |
Process for the production of a cephamycin derivative |
摘要 |
A chemotherapeutic, antibacterial agent, 7 beta -[(2D-2-amino-2-carboxy)ethylthioacetamido]-7 alpha -methoxy-3-[(1-methyl-1H-tetrazole-5-yl)thiomethyl]-3-cephem-4-carboxylic acid is produced economically and efficiently starting from cephamycin A and/or B by a "new route" process comprising the consecutive steps of reaction of cephamycin with 5-mercapto-1-methyl-1H-tetrazole; protection of the terminal amino group thereof by acylation; protection of the two carboxyl groups thereof by esterification; replacement of the acyl group initially having attached to the 7-amino group by a halogenoacetyl group; deprotection of the blocked 4-carboxyl group; and condensation of D-cysteine with the halogenoacetyl group attaching to the 7-amino group.
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申请公布号 |
US4302580(A) |
申请公布日期 |
1981.11.24 |
申请号 |
US19800185594 |
申请日期 |
1980.09.09 |
申请人 |
MEIJI SEIKA KAISHA, LTD. |
发明人 |
IWAMATSU, KATSUYOSHI;ITOH, JIRO;OMOTO, SHOJI;TSURUOKA, TAKASHI;INOUYE, SHIGEHARU |
分类号 |
C07D501/04;C07D501/36;C07D501/57;C12P35/08;(IPC1-7):C07D501/36 |
主分类号 |
C07D501/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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