| 发明名称 |
Antibody drug conjugates |
| 摘要 |
The present invention relates to anti-cKIT antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer. |
| 申请公布号 |
US9498543(B2) |
申请公布日期 |
2016.11.22 |
| 申请号 |
US201414205915 |
申请日期 |
2014.03.12 |
| 申请人 |
Novartis AG |
发明人 |
Abrams Tinya;Cohen Steven Bruce;Fanton Christie P.;Huber Thomas;Miller Kathy;Schleyer Siew Ho;Tissot-Daguette Kathrin Ulrike;Finner Catrin |
| 分类号 |
C07K16/00;A61K47/48;A61K49/00;A61K51/10;C07K16/28;A61K45/06;A61K31/537;A61K47/12;A61K47/26;C07K16/32;A61K39/00 |
主分类号 |
C07K16/00 |
| 代理机构 |
|
代理人 |
Carpenter David A. |
| 主权项 |
1. An antibody drug conjugate of the formula
Ab-(L-(D)m)n or a pharmaceutically acceptable salt thereof; wherein Ab is an antibody or antigen binding fragment thereof that comprises a heavy chain variable region that comprises: (a) a VH CDR1 of SEQ ID NO: 76, (b) a VH CDR2 of SEQ ID NO: 77, (c) a VH CDR3 of SEQ ID NO: 78; and a light chain variable region that comprises: (d) a VL CDR1 of SEQ ID NO: 85, (e) a VL CDR2 of SEQ ID NO: 86, and (f) a VL CDR3 of SEQ ID NO: 87 and specifically binds to an epitope of human cKIT at domains 1-3 (SEQ ID NO. 155); L is a linker; D is a drug moiety; m is an integer from 1 to 8; and n is an integer from 1 to 10. |
| 地址 |
Basel CH |
