发明名称 FREMGANGSMAADE TIL FREMSTILLING AF 3,4-DIISOBUTYRYLOXY-N-METYLFENAETYLAMIN ELLER FARMACEUTISK ACCEPTABLE SYREADDITIONSSALTE DERAF
摘要 <p>The invention provides novel compounds of formula …<CHEM>… in which R is isobutyryloxy and salts thereof, processes for making it and a new process for the preparation of therapeutically active 3,4-di-isobutyryloxy-N-methyl- phenethylamine (I) …<CHEM>… and its acid addition salts. According to the process 3,4-dimethoxyphenethylamine is reacted with benzaldehyde and formaldehyde in the presence of hydrogen and a catalyst to give a compound of formula (II) …<CHEM>… The compound (II) is demethylated to give …<CHEM>… and then reacted with isobutyryl chloride in the presence of a base to give a compound of formula IV …<CHEM>… from which the benzyl protecting group is removed by catalytical hydrogenation whereby compound (I) is obtained.</p>
申请公布号 DK234984(D0) 申请公布日期 1984.05.11
申请号 DK19840002349 申请日期 1984.05.11
申请人 *FARMOS-YHTYMAE OY 发明人 MAIRE M. *ELORANTA
分类号 C07B61/00;B01J23/00;B01J23/44;C07C;C07C67/00;C07C213/00;C07C219/28;(IPC1-7):C07C93/ 主分类号 C07B61/00
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