A novel physiologically active polypeptide.

摘要

A physiologically active polypeptide, Tumor Necrosis Factor (TNF), comprising a specific amino acid sequence of 154 amino acid residues. The base sequence of the DNA coding for the TNF has been determined by means of genetic manipulation techniques. The TNF can be advantageously produced on a large scale by recombinant DNA technique. The TNF of the present invention has been found to be excellent in inducing necrosis of tumors with no toxic effect upon the normal tissues of the living body.