| 摘要 |
PURPOSE:To obtain ribofuranan sulfate having an anticoagulant activity, by sulfating ribofuranan. CONSTITUTION:Ribofuranan sulfate of formula I (wherein n is 10-500 and R is H or SO3Na) is obtained by sulfating ribofuranan with a sulfating agent. When n in formula I is smaller than 10, the anticoagulant activity is decreased, while when it is larger than 500, the synthesis of this compound is difficult. Examples of the sulfating agents which can be used include sulfuric anhydride/ trimethylamine complex, chlorosulfonic acid and piperidine N-sulfate. Ribofuranan sulfate of formula I has an anticoagulant activity in the medical field and therefore a substance containing it as an effective component can be used as a medical polymeric material which must prevent coagulation of the blood, such as a material for artificial hearts and artificial blood vessels. Ribofuranan which is a starting material for ribofuranan sulfate can be obtained by, for example, a process shown in formula II (wherein Bn is CH2C6H5).
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