| 摘要 |
PCT No. PCT/GB83/00127 Sec. 371 Date Jan. 3, 1984 Sec. 102(e) Date Jan. 3, 1984 PCT Filed Apr. 28, 1983 PCT Pub. No. WO83/03830 PCT Pub. Date Nov. 10, 1983.Blood products and derivatives, such as procoagulants-e.g. Factor VIII and prothrombin-plasma proteins, immunoglobulin and complement growth factors and various leucocytes, are obtained from shed blood or its tissue precursor, bone marrow, that has been anticoagulated by the use of a neutral salt that does not bind calcium ions. The preferred anticoagulants are salts containing the divalent ions calcium, magnesium, barium or strontium. Salts of calcium and magnesium are especially preferred because of their relatively lower toxicity, the salt of choice being a magnesium salt, for instance magnesium chloride, because magnesium salts exhibit the required anticoagulating action at levels compatible with retention of normal ionic strength and osmolarity. The toxicity of the neutral salt is eliminated by its removal.
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