| 摘要 |
NEW MATERIAL:The compound of formula I (R1-R3 are H or methyl provided that at least one of them is methyl; Z is halogen or two Z form an O atom; Y is OH, halogen, etc., when Z is halogen and Y is amino when two Z form an O atom). EXAMPLE:2-Carbamoylethylgermanium sesquioxide. USE:A physiologically active substance useful as an antitumor agent, etc. It has high solubility and bioavailability. PREPARATION:The acrylic acid derivative of formula II is subjected to addition reaction with the trihalogermane of formula HGeX3 (X is halogen) to obtain the trihalogermylpropionic acid of formula III, which is made to react with a chlorination agent such as thionyl chloride. The produced compound of formula IV is amidated by reacting with dry ammonia in a solvent such as anhydrous benzene and the resultant trihaloamide compound is hydrolyzed to obtain the objective compound.
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