| 摘要 |
PURPOSE:To obtain the titled compound useful as a raw material for synthesizing naphthoquinone based medicines, e.g. shikonin, etc., in good yield in one process, by methylating readily available naphthazarin as a raw material with dimethyl sulfate while reacting sodium dithionite therewith. CONSTITUTION:Naphthazarin expressed by formula VIII is methylated by adding dimethyl sulfate expressed by the formula (CH3)2SO4 while being reacted and reduced with sodium dithionite expressed by the formula Na2S2O4 in an organic solvent, e.g. tetrahydrofuran, etc., at room temperature to afford the aimed compound expressed by formula VII. The resultant compound is used as a starting raw material or intermediate capable of exhibiting excellent effects on rationalizing synthesis of naphthoquinone based medicines, e.g. shikonin expressed by formula I, echinone expressed by formula II, mithoxanthrone expressed by formula III, etc., having antitumor, antimicrobial and anti- inflammatory action.
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