| 发明名称 |
Process for the manufacture of spiro-linked pyrrolidine 2,5-diones |
| 摘要 |
This invention relates to novel processes for the manufacture of spiro-linked pyrrolidine-2,5-diones of the formula; <IMAGE> which have a potent inhibitory activity on aldose reductase and are useful for reduction and prevention of chronic diabetic complications. The invented processes are useful as improved and convenient method for a large scale manufacture.
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| 申请公布号 |
US4749789(A) |
申请公布日期 |
1988.06.07 |
| 申请号 |
US19870072004 |
申请日期 |
1987.07.10 |
| 申请人 |
KYORIN PHARMACEUTICAL CO., LTD. |
发明人 |
MASUZAWA, KUNIYOSHI;OKAMURA, KYUYA;FUJIMORI, SHIZUYOSHI;KINOSHITA, SUSUMU;MATSUKUBO, HIROSHI |
| 分类号 |
C07B61/00;C07D471/20;C07D498/20;C07D513/20;(IPC1-7):C07D279/10;C07D295/08;C07D241/00 |
主分类号 |
C07B61/00 |
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