USE OF RECOMBINANT HUMAN ACTIVATED PROTEIN C TO ENHANCE VIABILITY OF TRANSPLANT TISSUE

摘要

The present invention relates to the use of activated Protein C (aPC) to enhance the viability of transplant graft. In certain instances, the invention provides methods of ex vivo perfusion of transplant graft with a composition comprising aPC. Further disclosed is a composition comprising activated Protein C (aPC), an isolated nucleic acid molecule encoding aPC, Protein C (PC), an isolated nucleic acid molecule encoding PC, or a combination thereof. In one embodiment, the composition comprises a crystalloid perfusate. In one embodiment, the composition comprises a whole-blood perfusate.