NEW AMINO ACID DERIVATIVE HAVING RENIN-INHIBITING ACTIVITY

摘要

NEW MATERIAL:A compound expressed by formula I {R<1> is expressed by formula II, R<12>-NH, R<13>-CO-Y or HO, etc., [R<10> and R<11> are: R<10> is alkyl and R<11> is expressed by formula III (R<111> is alkyl; n is 1-5), substitutable alkyl, or a group expressed by formula IV together with N; R<12> is H or CnH2n+1-O-CO, etc.; R<13> is substitutable alkyl; X is CH2, O or NH; Y is O or NH; formula IV is equal to formula V (Z is O, S, SO, CH2 or NH, etc.; a and b are 1-4 and a+b<=5)]; R<2> is substitutable aralkyl; R<3> is H or alkyl; R<4> is alkyl; A is OH; B is H or CO together with adjacent C}. EXAMPLE:(2S)-2-[N-{3-morpholinocarbonyl-2-(1-naphthyl methyl) propionyl}-L- hystidyl]amino-1-cyclohexyl-6-methyl-3,5-heptanediol. USE:Used as a persistent antihypertensive agent or an agent for cardiac failure. PREPARATION:A compound expressed by formula VI is reacted with a compound expressed by formula VII to afford the compound expressed by formula I.