发明名称 |
MANUFACTURING INTRAVENOUS TOLERABLE IMMUNOGLOBULIN-G PREPARATION |
摘要 |
Method of manufacturing an intravenously tolerable immunoglobulin-G preparation that is free of aggregates, vasoactive substances and proteolytic enzymes and accordingly appropriate for all types of patients, especially immunosuppressed patients, from a starting material that contains immunoglobulin G but from which the coagulation factors have been removed. The starting material is treated with 0.4 to 1.5% by volume of octanoic acid and then chromatographed, especially on an ion or cation exchanger or hydrophobic matrix.
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申请公布号 |
US5164487(A) |
申请公布日期 |
1992.11.17 |
申请号 |
US19910669782 |
申请日期 |
1991.03.15 |
申请人 |
BIOTEST PHARMA GMBH |
发明人 |
KOTHE, NORBERT;RUDNICK, DIETER;PIECHACZEK, DETLEF;KLEIN, HERWALD;ROHM, DETLEF;KLOFT, MICHAEL |
分类号 |
A61K39/395;A61K39/00;B01D15/08;C07K16/06 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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