发明名称 |
SUBSTITUTED 3,4-DIHYDRONAPHTHALENES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS AND PROCESSES FOR THE PREPARATION OF THESE COMPOUNDS AND COMPOSITIONS |
摘要 |
Substituted 3,4-dihydronaphthalenes of the formula I wherein R1 is the methyl or the amino group, R2 represents a hydrogen atom or the methyl group and R3 is a linear or branched chain alkyl residue having 1 to 4 carbon atoms, the allyl or the crotyl residue or a cyclopentyl group are disclosed which specifically inhibit 5-lipoxygenase and are useful in pharmaceutical compositions for prophylaxis and treatment of diseases due to the action of leukotrienes. The dihydronaphthalenes may be prepared by reacting a compound of formula II with hydroxylamine or a salt thereof to form the corresponding oxime, reducing the oxime to a hydroxylamine of formula III and introducing the residue -CO-R1.
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申请公布号 |
CA2070495(A1) |
申请公布日期 |
1993.01.24 |
申请号 |
CA19922070495 |
申请日期 |
1992.06.04 |
申请人 |
GRUENENTHAL G.M.B.H. |
发明人 |
ZIMMER, OSWALD;VOLLENBERG, WERNER;SCHNEIDER, JOHANNES |
分类号 |
A61K31/16;A61K31/17;A61P11/00;A61P11/06;A61P11/08;A61P31/04;A61P37/08;A61P43/00;C07C259/06;C07C275/64;(IPC1-7):C07C275/64 |
主分类号 |
A61K31/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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