TETRAHYDROTHIOPHENE DERIVATIVES

摘要

A compound of the formula ¢I! and pharmaceutically acceptable salts thereof; and a synthetic intermediate represented by the formula ¢II! and pharmaceutically acceptable salts thereof, ¢I! ¢II! wherein R 1 is hydrogen or lower alkyl; R 2 is hydrogen or a protective group of thiol; R 3 is hydroxy, a remainder of ester group or a remainder of amido group; A is straight or branched lower alkylene, and the sulfur atom in the side chain may be directly join with -CO- to conform a thiolactone ring. The compounds of this invention have excellent thymulin-like activities and are expected to be useful for treatment of various immune disorders such as immunodeficiency and autoimmune diseases.