RECOMBINATION TYPE APP SMALL GENE FOR INDICATION IN GENE EXCHANGEABLE MOUSE AS MODEL FOR ALZHEIMER'S DISEASE

摘要

Functional recombinant APP minigene constructs and their introduction into the germline of transgenic mice. Such transgenic mice are useful to generate models of Alzheimer's disease and pathogenesis and are also useful to identify molecular mechanisms of the pathogenesis of Alzheimer's disease.