| 摘要 |
FIELD: organic chemistry. SUBSTANCE: products: tetrahydroisoquinoline compounds of the formulaand their pharmaceutically acceptable salts where R- one or more substituents taken from H, halogen, hydroxy, alkyl (nonobligatory substituted with hydroxy), alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, nitro, cyano, polyhaloidalkyl, polyhaloidalkoxy, phenyl (nonobligatory substituted with one or more halogen, alkyl or alkoxy), or R- carbonyl nonobligatory substituted with carbamoyl; R- aliphatic group nonobligatory substituted with hydroxy or alkoxy; E - alkylene chain nonobligatory substituted with one or more alkyl groups; and G - phenyl or phenyl substituted with one or more alkyl, alkoxy, halogen, hydroxy, polyhaloidalkyl, polyhaloidalkoxy, cyano, alkylthio, alkylsulfinyl, alkylsulfonyl, phenyl (nonobligatory substituted with one or more halogen, alkyl or alkoxy), nonobligatory alkylated carbamoyl, or G - phenyl ring fused with heterocyclic or aromatic ring; and their O-acylated derivatives as lipophilic esters. Synthesized compounds were used as analgetics, for treatment of patients with psychosis (for example, schizophrenia), Parkinson disease, Lesch-Hyhan syndrome, and other disorders. EFFECT: improved method of synthesis. |
