| 主权项 |
1. Disintegratable porous organometaloxide material comprising a porous three-dimensional framework of metal-oxygen bonds, wherein at least a subset of metal atoms in the material's framework are connected to at least another metal atom in the framework through a linker having one of the following structures:
*—R1-L-R2—*, wherein:
each occurrence of * denotes a point of attachment to a metal atom in the material's framework;A represents a monomer of a responsively cleavable fragment of biological/biodegradable polymer;m is an integer from 2 to 10000 and m represents the number of monomers in the fragment of biological/biodegradable polymer;L represents a responsively cleavable covalent bond, andR1 and R2 independently represent an optionally substituted C1-20alkylenyl moiety, an optionally substituted C1-20heteroalkylenyl moiety, an optionally substituted ethylenyl moiety, —C≡C— or an optionally substituted phenyl moiety, wherein the C1-20alkylenyl, C1-20heteroalkylenyl or ethylenyl moiety may bear one or more substituents selected from halogen or —OR where R may represent H or C1-6alkyl, and the phenyl moiety may bear one or more substituents independently selected from halogen, C1-6alkyl, —NO2, —CN, isocyano, —ORp, —N(Rp)2 wherein each occurrence of Rp independently represents H or C1-6alkyl;wherein, when the linker has the structure *—R1-L-R2—*, the subset of metal atoms in the material's framework that are connected to the linker *—R1-L-R2-*, represent at least 30% of the metal atoms present in the porous organometaloxide material. |
