| 摘要 |
<p>PROBLEM TO BE SOLVED: To obtain the subject new nucleic acid compound which is a specific 4'-thioarabinopurine nucleoside, available from an inexpensive substance as a raw material according to simple operations, having excellent antiviral actions and useful as a medicine, etc., such as an antiviral agent. SOLUTION: This new 4'-thioarabinopurine nucleoside is represented by formula I (B is a purine base other than adenine) [e.g. 9-(4-thio-α-D- arabinofuranosyl)-2,6-diaminopurine], has excellent antiviral actions and is useful as a medicine, etc., such as an antiviral agent. The compound is obtained by introducing sulfonyl groups into the 2- and 5-positions of a compound represented by formula II (R<1> is an alkyl; R<2> is a protecting group of hydroxyl group), then reacting the resultant compound with a sulfide, forming a thio-D- arabinofuranose structure represented by formula III (R<4> and R<5> are each a protecting group of hydroxyl group), subsequently opening the ring, oxidizing the prepared compound, providing a sulfoxide derivative, then carrying out the Pummere rearrangement, converting the sulfoxide derivative into a compound represented by formula IV (Ac is acetyl) and introducing purine bases into the resultant compound.</p> |
