发明名称 |
METHODS FOR INDUCING ANTIGEN-SPECIFIC T CELL TOLERANCE |
摘要 |
<p>Antibodies that bind a protein gp39 (also referred to as CD40 ligand) are disclosed. Preferably, the antibodies are monoclonal antibodies of an IgG1 isotype and bind human gp39. In a preferred embodiment, an antibody of the invention binds an epitope recognized by a monoclonal antibody 24-31, produced by a hybridoma 24-31 (ATTC Accession No. HB11712) or binds an epitope recognized by a monoclonal antibody 89-76, produced by a hybridoma 89-76 (ATCC Accession No. HB 11713). Pharmaceutical compositions comprising the antibodies of the invention are also disclosed. The antibodies of the invention are useful for inhibiting B cell proliferation and differentiation, T cell responses and for inducing T cell tolerance. Nucleic acid molecules encoding anti-gp39 antibodies, or portions thereof, as well as expression vectors and host cells incorporating said nucleic acid molecules, are also encompassed by the invention.</p> |
申请公布号 |
GR3027658(T3) |
申请公布日期 |
1998.11.30 |
申请号 |
GR19980401834T |
申请日期 |
1998.08.14 |
申请人 |
TRUSTEES OF DARTMOUTH COLLEGE |
发明人 |
NOELLE, RANDOLPH, J.;FOY, TERESA, M.;DURIE, FIONA, H. |
分类号 |
A61K39/395;A61K31/00;A61K35/14;A61K35/28;A61K38/00;A61K38/17;A61P37/00;A61P37/06;C07K14/705;C07K16/28;C07K19/00;C12N5/10;C12N15/02;C12P21/08;C12R1/91;G01N33/68;(IPC1-7):A61K39/395 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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