| 摘要 |
PROBLEM TO BE SOLVED: To obtain the subject inhibitor capable of inhibiting the manifestation and progression of senile freckles or the like and suitable for preventing and improving pigmentation disorders in the form of cosmetics or the like, by using a specific essence. SOLUTION: This inhibitor comprises an essence from sanguisorbae radix. The essence is obtained by subjecting one or more kinds selected from the leaves, stems and branches of sanguisorbae radix to extraction with a polar solvent, and optionally, evaporating the solvent to dryness; specifically, it is recommended, for example, that the essence is obtained by adding methanol to the whole grass of sanguisorbae radix which is then immersed in the methanol at room temperature for 5 days followed by filtration to remove impurities, and then by evaporating the solvent under reduced pressures to dryness followed by subjecting the resultant residues to liquid-liquid extraction using methylene chloride and water. This inhibitor, when to be used in a cosmetic, is formulated pref. at 0.01-10 wt.% in the cosmetic. |
