发明名称 |
PROCEDURE FOR THE PREPARATION OF DIOXOPENICILLANIC ACID DERIVATIVES |
摘要 |
Procedure for the preparation of dioxopenicillanic acid derivatives and its salts pharmaceutically acceptable with general formula I, where, R is hydrogen, alkyl group containing 1 to 5 Carbon atoms or a residue of type -CH2R', where R' is hydrogen, halogen or a p-toluensulfonyl group. These are prepared by treatment of the compounds of general formula II, where R is as previously defined and X may be hydrogen or bromine, with a metallic reagent constituted by a mixture or alloy of copper and/or cobalt and/or manganese with iron and/or nickel in an aqueous/organic medium. These compounds are useful as inhibitors of beta-lactamase. (see formula I)
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申请公布号 |
CA2299959(A1) |
申请公布日期 |
2000.09.03 |
申请号 |
CA20002299959 |
申请日期 |
2000.02.29 |
申请人 |
ALEX-GYOGYSZER KUTATASI, FEJLESZTESI ES TANACSADO KORLATOLT FELLOSSEGU T ARSAGAG |
发明人 |
DE LA FUENTE MORATA, JUAN PEDRO |
分类号 |
C07D277/60;C07D499/00;C07D499/04;C07D499/86;(IPC1-7):C07D499/04 |
主分类号 |
C07D277/60 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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