发明名称 |
Materials and methods relating to neuronal development |
摘要 |
The invention relates to the induction of the neuronal fate in neural stem cells or neural progenitor cells. The inventors have found that a neuronal fate in a neural stem cell or neural progenitor cell can be induced by expressing Nurr1 above basal levels within the cell. Nurr1 is a transcription factor of the thyroid hormone/retinoic acid nuclear receptor superfamily. It is shown herein that the expression of Nurr1 above basal levels in neural stem cells or neural progenitor cells increases the proportion of the cells which differentiate toward a neural fate. It has been found that in particular, dopaminergic neural stem cells or progenitor cells by a process including expression of Nurr1 above basal levels in the cells and contact of the cells with one or more factors supplied by or derived from Type I astrocytes of the ventral mesencephalon. |
申请公布号 |
AU4752700(A) |
申请公布日期 |
2000.11.17 |
申请号 |
AU20000047527 |
申请日期 |
2000.04.27 |
申请人 |
KAROLINSKA INNOVATIONS AB |
发明人 |
ERNEST ARENAS;THOMAS PERLMANN;EVAN Y. SNYDER;JOSEPH WAGNER;PETER AKERUD |
分类号 |
G01N33/50;A61K35/12;A61K35/30;A61K45/00;A61P25/28;C12N5/0793;C12N5/10;C12Q1/02;G01N33/15 |
主分类号 |
G01N33/50 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|