Pharmaceutical composition associated with hydrogel particles for administration by transdermal delivery from a needless syringe

摘要

Compositions formed from the combination of an active substance with a hydrogel carrier moiety are provided. The compositions are suitable for use in high-velocity transdermal particle injection techniques. Methods of providing the new compositions are also provided. In addition, methods for administering pharmacologically active agent to a subject are provided. These methods are useful for delivering drugs, biopharmaceuticals, vaccines and diagnostic agents. The results of the study for 4% agarose beads are presented in the figure. The maximum % insulin loading by theoretical calculation in a single loading step is 37.5% for 4% agarose beads, compared with 22.3% for 8% agarose beads (not shown). As can be seen by these results, the multiple (iterative) loading method described herein is suitable to provide for extremely high drug loading per particle on a dry weight basis.