Compositions and methods for modulating an immune response

摘要

The invention generally features compositions and methods for modulating an immune response. In particular embodiments, such compositions and methods modulate regulatory T cell suppressive activity.

主权项

1. A method for identifying candidate compound that increases effector T cell-mediated immune response, the method comprising:
(a) obtaining a sample of a T lymphocytes that express Helios and comprise a FoxP3 promoter; (b) contacting the T lymphocytes of (a) with a candidate compound or a control agent for a sufficient period of time; (c) detecting binding of Helios to the FoxP3 promoter in the T lymphocytes of (b); (d) determining that the candidate compound increases effector T cell-mediated immune response when the compound decreases binding of Helios to the FoxP3 promoter in the T lymphocytes contacted with the candidate compound when compared to the binding of Helios to the FoxP3 promoter in the T lymphocytes contacted with the control agent.