Method for the preparation of cephalosporin derivatives

摘要

A method for the preparation of 3-carbamoyloxymethyl-7-methoxy-7-(2-[2-thienyl]acetamido)decephalospor anic acid and its salt and ester derivatives, which comprises treating a 3-carbamoyloxymethyl-7-methoxy-7-(halo or metallo-substituted lower alkanamido)decephalosporanate with a 2-thienyl halide or metallide or with a 2-thenyl halide or metallide. The decephalosporanic acid product thus obtained and its salts are antibiotics which have utility against gram-positive and gram-negative bacteria.