CONDENSATION POLYMERS FOR ANTIMICROBIAL APPLICATIONS

摘要

A number of cationic antimicrobial polymers have been synthesized by a condensation polymerization in bulk. The initial polymer formed has backbone tertiary nitrogens, which are subsequently quaternized using a suitable quaternizing agent (e.g., alkyl halide). The cationic polymers include polyamides, polycarbonates, polypolyureas and polyguanidiniums having a cationic repeat unit comprising the quaternary ammonium nitrogen as a backbone nitrogen. The cationic polymers can be active against Gram-negative, Gram-positive microbes, and/or fungi.

主权项

1. A cationic polymer, comprising:
a cationic repeat unit of formula (1): wherein
W′ is a single bond or a divalent linking group having a structure *—C(═O)-L′-*, wherein L′ is divalent radical comprising 1-20 carbons and L′ is linked to carbon 1,La and Lb are independent divalent hydrocarbon groups comprising 2-20 carbons, andQ′ is a divalent radical selected from group consisting of wherein Ra, Rb, Rc, Rd, Re are independent monovalent hydrocarbon groups comprising 1-20 carbons and each X− is an independent negative-charged counterion, and
adjacent repeat units of the cationic polymer are covalently linked in a head-to-tail arrangement, wherein nitrogen labeled 2 is designated a tail and W′ is designated a head.