| 主权项 |
1. A human antibody, or a functional part or a functional equivalent thereof:
wherein said human antibody or functional part or functional equivalent is isolated, synthetic or recombinant; wherein said human antibody or functional part or functional equivalent is able to bind a cell surface component of acute myeloid leukemia (AML) cells and diminish proliferation of AML cells essentially independently from antibody-dependent cell-mediated cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC), apoptosis, or phagocytosis by macrophages or dendritic cells; wherein said human antibody or functional part or functional equivalent is coupled to another compound; and wherein said other compound is a detectable label, a chemotherapeutic drug, a toxic moiety, an immunomodulatory molecule, another AML-specific binding compound, or a radioactive compound. |
