| 发明名称 |
PRODRUG FOR RELEASE OF CISPLATIN AND CYCLOOXYGENASE INHIBITOR |
| 摘要 |
Pt(IV) prodrugs include one or more conjugated cyclooxygenase inhibitor. Reduction of Pt(IV) to Pt(II) can result cisplatin and a cyclooxygenase inhibitor. For proof of concept, a Pt(IV) prodrug that can produce cisplatin and aspirin, Platin-A, was synthesized. Platin-A exhibited excellent anticancer and anti-inflammatory properties, which were better than the combination of free formulation of cisplatin and aspirin. |
| 申请公布号 |
US2016326200(A1) |
申请公布日期 |
2016.11.10 |
| 申请号 |
US201415102700 |
申请日期 |
2014.12.12 |
| 申请人 |
UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. |
发明人 |
Dhar Shanta;Pathak Rakesh |
| 分类号 |
C07F15/00 |
主分类号 |
C07F15/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A Pt(IV) compound having a structure as follows:where:
R1 is -(L1)m-(R3)n; R2 is OH or -(L2)x-(R4)y; R3 is a conjugated cyclooxygenase inhibitor; R4 is a conjugated cyclooxygenase inhibitor or a targeting moiety, wherein if R4 is a conjugated cyclooxygenase inhibitor, R3 and R4 are the same or different; L1 is a linker; L2 is a linker, wherein L1 and L2, if both are present, are the same or different; m and x are independently zero or one; and n and y are independently an integer greater than or equal to 1. |
| 地址 |
Athens GA US |
