发明名称 |
2-Amino-3,4-dihydropyridines used to effect coronary vessel dilation and treat hypertension |
摘要 |
3-Substituted 2-amino-3,4-dihydropyridine-3-carboxylic acid esters are produced by reacting 2-amino-1,4-dihydropyridine-3-carboxylic acid esters with an alkylating agent in the presence of an inert organic solvent at a temperature of from 20 DEG C to 200 DEG C. The compounds, of which 2-amino-3,6-dimethyl-4-phenyl-3,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester is a typical embodiment, possess antihypertensive and coronary dilating properties.
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申请公布号 |
US4002762(A) |
申请公布日期 |
1977.01.11 |
申请号 |
US19750544934 |
申请日期 |
1975.01.28 |
申请人 |
BAYER AKTIENGESELLSCHAFT |
发明人 |
MEYER, HORST;BOSSERT, FRIEDRICH;VATER, WULF;STOEPEL, KURT |
分类号 |
C07D211/90;(IPC1-7):A61K31/45 |
主分类号 |
C07D211/90 |
代理机构 |
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地址 |
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