ANALOGIFREMGANGSMAATE FOR FREMSTILLING AV NYE, FARMAKOLOGISK AKTIVE PENTANOLDERIVATER

摘要

1384442 1 - Alkyl - 2 - propyl - pentanols and their carbamates LABAZ 19 June 1973 [29 June 1972] 30600/72 Heading C2C Novel compounds I (C 3 H 7 ) 2 CH-CH(OR 1 )-R in which R is C 1-4 alkyl and R 1 is hydrogen or -CONH 2 with the proviso that when R 1 is hydrogen R is other than methyl are prepared by reacting a ketone (II) (C 3 H 7 ) 2 CH-CO-R with a reducing agent (preferably sodium borohydride or hydrogen in the presence of a catalyst) in an inert solvent to form the alcohol of Formula I which if desired is reacted with phosgene at room temperature in an inert solvent followed by condensation with ammonia. Ketones II are prepared by reacting 2-npropyl-valeronitrile with the appropriate alkyl magnesium halide and hydrolysing the complex formed or by treating 2-n-propyl-valeryl chloride with the appropriate alkyl cadmium chloride. Compounds I and 3-propyl-2-hexanols have anti-depressant, tranquilizing and sedating properties and form with a carrier or excipient a pharmaceutical composition which may be administered orally, parenterally or rectally.